If a person use an anal or vaginal suppository, is the ghusl wajib?
An obligatory ghusl is necessitated when one of the following occurs (Minhaj al-Talibin 78),
1) Death [mawt].
2) Menstruation [hayd].
3) Childbed [nifas].
4) Child birth [wiladah] according to the relied-upon view [al-asahh].
5) A state of major ritual impurity [janabah]. This state occurs when a male part penetrates a female part or by ejaculation.
Nothing besides these will necessitate an obligatory ghusl.
Allah knows best.
Answered by Shaykh Yaqub Abdurrahman